Challenges to antimicrobial susceptibility testing of plant-derived polyphenolic compounds

Plant-derived compounds in treatment of leishmaniasis

Leishmaniasis is a neglected public health problem caused by the protozoan species belonging to the genus Leishmania affecting mostly the poor populations of developing countries. The causative organism is transmitted by female sandflies. Cutaneous, mucocutaneous, and visceral clinical manifestations are the most frequent forms of leishmaniasis. Chemotherapy still relies on the use of pentavale...

Food as medicine: potential therapeutic tendencies of plant derived polyphenolic compounds.

The last two decades have witnessed a major drift in the interests of the scientific community towards explaining better means to containing the health risks of the human race. The century old chemotherapies against various disorders have never been a success, albeit not a total failure. Such therapies have a major drawback of side effects that give rise to unseen disorders that emerge as a new...

Antimicrobial susceptibility testing issues relating to EARSS

Antimicrobial Susceptibility Testing of Cefoperazone

Cefoperazone is a new cephalosporin with a very wide spectrum of activity, including activity against Pseudomonas aeruginosa. It has less activity on enterococci and Acinetobacter. Of the 459 selected bacterial strains tested in this study, only 1.5% (7 strains and 6 genera) had minimum inhibitory concentrations of >128 ,ug/ml. For a minimum inhibitory concentration breakpoint of <32 p.g/ml (su...

Instrumentation in antimicrobial susceptibility testing.

Studies in the 1960s demonstrated the problems of variability in susceptibility testing methods, especially those affecting the performance of disc diffusion procedures. These studies made apparent the need for standardization and resulted in more clearly defined performance limits for growth medium, incubation conditions, inoculum concentration, disc content for diffusion methods, the setting ...